Assessment of antibacterial activity of vinyltriphenylphosphonium hexabromoplatinate

Introduction. One of the biological effects platinum compounds is antibacterial action against Gram-positive and Gram-negative bacteria. Thus, some may inhibit synthesis DNA, RNA proteins in Escherichia coli cells.Aim — to study effect vinyltriphenylphosphonium hexabromoplatinate (VH) E. Staphylococcus aureus bacteria.Materials methods. The VH was studied by quantitation grown colonies strain ATCC 25922 S. 6538 on a nutrient medium test (suspension microorganisms, solution substance) control microorganisms). significance differences between outcomes groups estimated two-sided Fisher's exact test.Results. minimum inhibitory concentration for 14,0625 µg/ml, 225 µg/ml.Conclusion. exhibits more pronounced compared observed (14,0625 11,17 µM) comparable effective concentrations antitumor therefore, further studies with this bacterium, including vivo studies, are promising.